The best Side of Promethazine With Codeine
The best Side of Promethazine With Codeine
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The concomitant use of opioids with other medicines that have an impact on the serotonergic neurotransmitter procedure has resulted in serotonin syndrome.
It truly is soluble in water and freely soluble in Alcoholic beverages. The molecular body weight is 320.88. Its molecular method is C17H20N2S•HCl, and it has the subsequent chemical construction.
Use caution When thinking about the usage of Promethazine with Codeine Oral Option in people sixty five decades of age or more mature. Aged clients could possibly have greater sensitivity to codeine; bigger frequency of lessened hepatic, renal, or cardiac functionality; or concomitant disease or other drug therapy [see Warnings and Safety measures ( five.6) ]. Respiratory depression is the Main possibility for elderly individuals handled with opioids, such as Promethazine with Codeine Oral Solution. Respiratory despair has transpired right after huge initial doses of opioids were being administered to clients who were not opioid-tolerant or when opioids were co-administered with other brokers that depress respiration [see Warnings and Precautions ( five.
If you use codeine while you are Expecting, your toddler could develop into dependent on the drug. This may cause life-threatening withdrawal indications in the child immediately after it really is born. Toddlers born dependent on habit-forming medicine may need healthcare therapy for quite a few months.
Disorders OF USE: The information On this database is intended to nutritional supplement, not substitute for, the expertise and judgment of healthcare professionals. The information just isn't meant to include all feasible employs, Instructions, safeguards, drug interactions or adverse outcomes, nor really should it's construed to point that usage of a selected drug is Risk-free, acceptable or powerful for yourself or everyone else.
Normally talk to your Health care service provider to ensure the information shown on this website page applies to your personal situation.
Promethazine hydrochloride wasn't mutagenic from the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
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Promethazine Promethazine is often a phenothiazine by-product, which differs structurally in the antipsychotic phenothiazines by the existence of a click here branched side chain and no ring substitution.
As a result of danger of respiratory despair, keep away from the use of opioid antitussives, which include Promethazine with Codeine Oral Remedy in patients with compromised respiratory purpose, individuals liable to respiratory failure, and in aged, cachectic, or debilitated individuals.
Keep at room temperature faraway from light and dampness. Do not keep in the bathroom. Tend not to freeze. Keep all drugs clear of youngsters and pets.
Carcinogenicity studies were performed with promethazine hydrochloride. Two-yr reports in F344/N rats and B6C3F1 mice were done to evaluate the carcinogenic probable of promethazine hydrochloride. No proof of tumorigenicity was noticed in male and woman rats at promethazine hydrochloride oral doses nearly 33 mg/kg/working day for 5 days/week (roughly similar to 10 occasions the MRHD on the mg/m2 basis).
You should not use Promethazine VC with Codeine If you're allergic to codeine, phenylephrine, or promethazine, or When you have:
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